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Elevation of serum placental alkaline phosphatase levels in cigarette smokers

✍ Scribed by Susan E. Tonik; Ann E. Ortmeyer; Jeffrey E. Shindelman; Howard H. Sussman

Publisher
John Wiley and Sons
Year
1983
Tongue
French
Weight
337 KB
Volume
31
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

In an ongoing longitudinal study for tumor markers in breast cancer patients, levels of placental alkaline phos‐phatase (PAP) measured by RIA were found to be elevated in 34% of patients who smoked cigarettes as opposed to 5 % of non‐smoking subjects. A normal range was established (0‐2.14 ng/ml) using healthy non‐smoking females. In an expanded analysis by disease state, PAP levels were found to be elevated significantly (p<0.02) in the smoking groups of each category. This isoenzyme, when detected at elevated serum levels by RIA, was enzymatically active in 48% of the patients as analyzed by immunoenzymatic assay. One smoker with high PAP levels discontinued smoking following a myocardial infarction. Her PAP levels returned to normal within 2 months.

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