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Analysis of naltrexone and its metabolite 6-β-naltrexol in serum with high-performance liquid chromatography

✍ Scribed by Pekka Heinälä, Tuuli Lahti, David Sinclair, Kari Ariniemi, Pirjo Lillsunde, Hannu Alho


Book ID
119912824
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
204 KB
Volume
5
Category
Article
ISSN
1756-0500

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A sensitive and specific high-performance liquid chromatographic method with electrochemical detection was developed for the simultaneous determination of naltrexone and its major metabolite, 6-beta-naltrexol, in human plasma. After alkalinizing 2 ml plasma samples with pH 9 sodium carbonate buffer,