Determination of naltrexone and 6β-naltrexol in human blood: comparison of high-performance liquid chromatography with spectrophotometric and tandem-mass-spectrometric detection
✍ Scribed by Sonja Brünen; Ralf Krüger; Susann Finger; Felix Korf; Falk Kiefer; Klaus Wiedemann; Karl J. Lackner; Christoph Hiemke
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 305 KB
- Volume
- 396
- Category
- Article
- ISSN
- 1618-2650
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A sensitive and specific high-performance liquid chromatographic method with electrochemical detection was developed for the simultaneous determination of naltrexone and its major metabolite, 6-beta-naltrexol, in human plasma. After alkalinizing 2 ml plasma samples with pH 9 sodium carbonate buffer,
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