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Determination of naltrexone and 6β-naltrexol in plasma by high-performance liquid chromatography with coulometric detection

✍ Scribed by Piergiorgio Zuccaro; Ilaria Altieri; Peppino Betto; Roberta Pacifici; Giuseppe Ricciarello; Luigi Alberto Pini; Emilio Sternieri; Simona Pichini

Publisher
Elsevier Science
Year
1991
Weight
343 KB
Volume
567
Category
Article
ISSN
0378-4347

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A sensitive and specific high-performance liquid chromatographic method with electrochemical detection was developed for the simultaneous determination of naltrexone and its major metabolite, 6-beta-naltrexol, in human plasma. After alkalinizing 2 ml plasma samples with pH 9 sodium carbonate buffer,