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Analysis of deletions of the long arm of chromosome 11 in hematologic malignancies with fluorescence in situ hybridization

✍ Scribed by Hirofumi Kobayashi; Rafael Espinosa III; Anthony A. Fernald; Catherine Begy; Manuel O. Diaz; Michelle M. Le Beau; Dr. Janet D. Rowley

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 540 KB
Volume: 8
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870080407

No coin nor oath required. For personal study only.

✦ Synopsis

W e studied samples containing deletions of the long arm of chromosome I I (I I q) from patients with hematologic malignancies by using cytogenetic and fluorescence in situ hybridization (FISH) techniques. Cytogenetic analysis of 28 patients and of a cell line showed that all deletions included band I lq23. FISH analysis demonstrated that the proximal part of I lq23, including NCAM, was deleted in I 3 of I 5 patients and the cell line. Recurring chromosomal losses in human tumors have been regarded as evidence that the affected regions contain tumor-suppressor genes. These results suggest that the putative tumor-suppressor gene is proximal to the M U gene which is also located in I lq23. Genes Chrom Cancer 8:246-252 (l993).

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