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Frequent deletions of material from chromosome arm 1p in oligodendroglial tumors revealed by double-target fluorescence in situ hybridization and microsatellite analysis

✍ Scribed by Naoya Hashimoto; Daisuke Ichikawa; Yoshiki Arakawa; Kousei Date; Satoshi Ueda; Yoshio Nakagawa; Akira Horii; Yusuke Nakamura; Tatsuo Abe; Dr. Johji Inazawa

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 475 KB
Volume: 14
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870140408

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✦ Synopsis

We undertook a cytogenetic analysis of 29 human brain tumors using double-target fluorescence in situ hybridization (FISH) and focusing on chromosome arm I p. One or more tumor suppressor genes in this arm have been suggested t o be important in a variety of neuroectodermal tumors. The series included 9 oligodendrogliomas, 4 mixed gliomas, 10 astrocytomas, 4 glioblastomas, and 2 central neurocytomas. We hybridized pericentromeric ( I q 12) and subtelomeric ( I p36) DNA probes to cell nuclei prepared from pamffin-embedded tissues and observed a strikingly high incidence of deletion of at least part of I p in oligodendrogliomas (lOO%) and mixed gliomas (75%). The results of the FISH analyses were confirmed by demonstration of loss of heterozygosity for a microsatellite polymorphism in 10 of the 29 tumors. As well as supporting the feasibility of FISH for detecting allelic deletions in chromosomes from paraffin-embedded tumor samples, the alteration of I p reported here will contribute to an understanding of the molecular genetic events in oligodendroglial tumor development. Genes Chrornosorn --Cancer 14:295-300 (1995).

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