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Do terminal deletions of 11q23 exist? Identification of undetected translocations with fluorescence in situ hybridization

✍ Scribed by Hirofumi Kobayashi; Rafael Espinosa III; Michael J. Thirman; Anthony A. Fernald; Kevin Shannon; Manuel O. Diaz; Michelle M. le Beau; Dr. Janet D. Rowley

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 376 KB
Volume: 7
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870070404

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✦ Synopsis

Fluorescence in situ hybridization (FISH) was performed on bone marrow or peripheral blood cells thought to contain a del( I l)(q23q25) from four patients who had acute leukemia or myelodysplasia. Cells from all patients were shown to contain translocations that involved chromosome 6 in three of them. Our data suggest that a large proportion of presumptive del( I l)(q23) or del( I l)(q23q25) chromosomes may represent previously unidentified translocations that can be detected by FISH. Genes Chrorn Cancer 7: 204-208 (1993).

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