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Analysis of breast cancer pedigrees using affected sibship methods

✍ Scribed by Dr. Jennifer H. Barrett; Alan S. Rigby

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 279 KB
Volume: 12
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370120653

No coin nor oath required. For personal study only.

✦ Synopsis

Haplotype-sharing was examined in sets of affected siblings in the Breast Cancer Linkage Consortium pedigrees [Easton et al., 19931, using both identity-bydescent and identity-by-state methods. Linkage of the disease susceptibility locus to markers on chromosome 17 was confirmed. Substantial genetic heterogeneity was found, with more young cases being attributable to the putative gene. No differences were found between breast and ovarian cancer, and there was no evidence against a simple dominant mode of inheritance. 1995 Wiley-Liss, Inc.

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