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Genetic epidemiology of breast cancer: Segregation analysis of 200 Danish pedigrees

✍ Scribed by Wick R. Williams; David E. Anderson; D. C. Rao

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
965 KB
Volume
1
Category
Article
ISSN
0741-0395

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✦ Synopsis

An investigation of the genetic epidemiology of breast cancer involving complex segregation analysis of 200 breast cancer pedigrees of Danish extraction is presented. The observed distribution of breast cancer is compatible with transmission of an autosomai-dominant gene with no evidence for residual family resemblance. The gene frequency of the abnormal allele is 0.00756, and the displacement between the homozygous genotype means is 1.695. The gene frequency accounts for a significant proportion of breast cancer in young women, whereas by an advanced age a majority (87%) of affected women are phenocopies. Genetic modeling of other breast cancer families and results of linkage studies are reviewed.

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19841 recently presented a segregation analysis of 200 families of breast cancer patients published some 40 years ago. Unfortunately, in their discussion of work done by others Go et al, 1983; Cleton et al, 19831, they made some statements that could be misunderstood. It is our purpose here to clar