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Genetic epidemiology of breast cancer: Segregation analysis of 389 Icelandic pedigrees

✍ Scribed by Agnes B. Baffoe-Bonnie; Terri H. Beaty; Joan E. Bailey-Wilson; Lambertus A.L.M. Kiemeney; Helgi Sigvaldason; Gud̄rid̄ur Ólafsdóttir; Laufey Tryggvadóttir; Hrafn Tulinius

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
96 KB
Volume
18
Category
Article
ISSN
0741-0395

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✦ Synopsis

A genetic epidemiologic investigation of breast cancer involving 389 breast cancer pedigrees including information on 14,721 individuals from the Icelandic population-based cancer registry is presented. Probands were women born in or after 1920 and reported to have breast cancer in the cancer registry. The average age of the 389 probands was 45.5 years (SD 8.92). Segregation analyses was performed evaluating residual maternal effects, a dichotomous cohort effect, and assuming the age at diagnosis followed a logistic distribution after log-transformation. Familial aggregation could be best explained by the inheritance of a high-risk allele leading to early onset breast cancer among the homozygotes, which represent approximately 2.6% of the population. A Mendelian codominant model was selected as the best fitting model, with an estimated age at diagnosis of 51.8 years among these high-risk homozygotes, 64.0 years for heterozygotes and 76.3 years for the low-risk genotype.

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