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Analysis of Aneuploidy Frequencies in Sperm from Patients with Hereditary Nonpolyposis Colon Cancer and an hMSH2 Mutation

✍ Scribed by R.H. Martin; J. Green; E. Ko; L. Barclay; A.W. Rademaker


Book ID
117853201
Publisher
American Society of Human Genetics
Year
2000
Tongue
English
Weight
63 KB
Volume
66
Category
Article
ISSN
0002-9297

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Germ line mutations of hMSH2 and hMLH1 g
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Mutations in hMSH2 and hMLH1 genes were analyzed in patients from 11 Japanese families that had been diagnosed as carrying hereditary nonpolyposis colorectal cancer (HNPCC) by clinical examination. Germ line mutations of hMSH2 gene were identified in 5 independent families in which colorectal (87% o