Analog of doisynolic acid. 3-Hydroxy-16,17-seco-16-norestra-1,3,5(10)-trien-17-oic acid
β Scribed by Bielefeld, Marley A.; Oslapas, Raymond
- Book ID
- 126954824
- Publisher
- American Chemical Society
- Year
- 1969
- Tongue
- English
- Weight
- 501 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0022-2623
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Deuterium NMR spectroscopy has been used to show that a previously published synthesis of t6d,17r-epoxy-3-hydroxy-~~-3H]oestra~~l,3,5(10)-triene is not regiospecific but leads to additional isotope incorporation at positions -2 and/or -4. A modified synthesis i s described which leads to the title c
This communioation is ooncerned with the isolation of 3-oxo-16g-aoetoxyfusida-l,l7(2O)[16,U-ois),24-trlen-2l-olo acid from the culture broth of Cenhalosnorlum caerulens and elucidation of its struoture (IIa). After removal of a great part of helvolio acid (Ia) (1) from the extraot. ed metabolites m