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Evaluation of biological activity of new hemiesters of 17-hydroxy-16,17-secoestra-1,3,5(10)-triene-16-nitrile

✍ Scribed by Suzana S. Jovanović-Šanta; Silvana Andrić; Nebojša Andrić; Gordana Bogdanović; Julijana A. Petrović


Book ID
105771166
Publisher
Springer-Verlag
Year
2010
Tongue
English
Weight
335 KB
Volume
20
Category
Article
ISSN
1054-2523

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Deuterium NMR spectroscopy has been used to show that a previously published synthesis of t6d,17r-epoxy-3-hydroxy-~~-3H]oestra~~l,3,5(10)-triene is not regiospecific but leads to additional isotope incorporation at positions -2 and/or -4. A modified synthesis i s described which leads to the title c