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Synthesis of isomeric 16,17-epoxy-[17-3H)-derivatives of 3-hydroxy and 3-methoxy-oestra-1,3,5(10)-trienes

✍ Scribed by G. Michael Blackburn; Brian F. Taylor; Andrew F. Worrall

Publisher
John Wiley and Sons
Year
1986
Tongue
French
Weight
373 KB
Volume
23
Category
Article
ISSN
0022-2135

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✦ Synopsis

Deuterium NMR spectroscopy has been used to show that a previously published synthesis of t6d,17r-epoxy-3-hydroxy-~~-3H]oestra~~l,3,5(10)-triene is not regiospecific but leads to additional isotope incorporation at positions -2 and/or -4. A modified synthesis i s described which leads to the title compounds exclusively labelled at position -17.

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