Steroids, XLII. Configurational analysis of 3-methoxy-16-methylestra-1,3,5(10)-trien-17-ol derivatives
✍ Scribed by Meskó, Eszter ;Schneider, Gyula ;Dombi, György ;Zeigan, Dieter
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 332 KB
- Volume
- 1990
- Category
- Article
- ISSN
- 0947-3440
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✦ Synopsis
Abstract
The four possible isomers of 16‐hydroxymethyl‐3‐methoxyestra‐1,3,5(10)‐trien‐17‐ol 5a, 6a, 7a, 8a were converted into the corresponding 16‐methyl analogues 4a, 11a, 12a, 13a, which were characterized from their ^1^H‐ and ^13^C‐NMR spectra. The results permit a configurational correlation with 16‐methyl derivatives reported in the literature.
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Deuterium NMR spectroscopy has been used to show that a previously published synthesis of t6d,17r-epoxy-3-hydroxy-~~-3H]oestra~~l,3,5(10)-triene is not regiospecific but leads to additional isotope incorporation at positions -2 and/or -4. A modified synthesis i s described which leads to the title c
The Crystal Structure of 3-Methoxy-estra-1,3,5(10) triene-16aBrJ7aOH Dedicated to Professor Kate BOLL-DORNBEROER on the occasion of her 70th birthday The steroid 3-Methoxy-estra-1,3,5( lO)triene-l6aBr, 17aOH crystallizes in the orthorhombic space group P 2,2,2, with lattice constants a = 30.653( 5
## Abstract The synthesis of a [9α, 11α‐]‐tritium‐labelled new steroid with interceptive — post‐coital antifertility — activity, 3‐methoxy‐14β, 15β‐methylene‐estra‐1,3,5(10)‐triene‐17β‐ol, starting with the catalytic tritiation of 3‐methoxy‐estra‐1,3,5(10), 9(11)‐tetraene‐14α, 17β‐diol, is describe