✦ LIBER ✦
Tritiummarkierung Eines Neuen Steroids mit Fertilitätshemmenden Eigenschaften: 3-methoxy-14β, 15β-methylen-[9α, 11α-3H]-Östra-1,3,5(10)-trien-17β-OL
✍ Scribed by H. Wagner; J. Römer; H. Kasch
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- French
- Weight
- 404 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
The synthesis of a [9α, 11α‐]‐tritium‐labelled new steroid with interceptive — post‐coital antifertility — activity, 3‐methoxy‐14β, 15β‐methylene‐estra‐1,3,5(10)‐triene‐17β‐ol, starting with the catalytic tritiation of 3‐methoxy‐estra‐1,3,5(10), 9(11)‐tetraene‐14α, 17β‐diol, is described.
3‐Methoxy‐14β, 15β‐methylene‐[9α, 11α‐^3^H]‐estra‐1,3,5(10)‐triene‐17β‐ol was obtained in a four‐step synthesis with high specific activity (3,8 Ci/mmole) and radiochemical purity better than 99 %. Radiolysis and storage conditions are examined.