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Isolation and Structural Elucidation of 3-oxo-16β-acetoxyfusida-1, 17(20)(16,21-cis),24-trien-21-oic acid

✍ Scribed by Shigenobu Okuda; Yoshihiro Sato; Tetsuyasu Hattori; Mikio Wakabayashi

Publisher: Elsevier Science
Year: 1968
Tongue: French
Weight: 247 KB
Volume: 9
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)72772-9

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✦ Synopsis

This communioation is ooncerned with the isolation of 3-oxo-16g-aoetoxyfusida-l,l7(2O)[16,U-ois),24-trlen-2l-olo acid from the culture broth of Cenhalosnorlum caerulens and elucidation of its struoture (IIa).

After removal of a great part of helvolio acid (Ia) (1) from the extraot. ed metabolites mixture by recrystallization, a careful separation of the mother liquor by silioa gel column ohromatography gave a crystalline acid (yield: 1.57 mg/lOOO ml) eluted just before the Ia fraction. The free acid (11s): m.p. 204O,

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