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An unprecedented and highly chemoselective esterification method

✍ Scribed by Adam Shih-Yuan Lee; Hui-Chun Yang; Feng-Yih Su

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
54 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

A series of carboxylic acids was transformed to their corresponding methyl esters under CBr 4 /CH 3 OH (0.05 eq., 5 ml) reaction conditions. The rate of esterification is decreased with increasing bulkiness of the alcohol. Chemoselectivity can be achieved between phenylacetic and benzoic acids, sp 3 -C and sp 2 -C acids as well as between sp 3 -C and sp-C tethered carboxylic acids.

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