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An investigation on stereospecific fluorination at the 2′-arabino-position of a pyrimidine nucleoside: radiosynthesis of 2′-deoxy-2′-[18F]fluoro-5-methyl-1-β-d-arabinofuranosyluracil

✍ Scribed by Nashaat Turkman; Vincenzo Paolillo; Juri G. Gelovani; Mian M. Alauddin

Book ID
119375813
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
383 KB
Volume
68
Category
Article
ISSN
0040-4020

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📜 SIMILAR VOLUMES

A general synthesis of 2′-deoxy-2′-[18F]
A general synthesis of 2′-deoxy-2′-[18F]fluoro-1-β-D-arabinofuranosyluracil and its 5-substituted nucleosides
✍ Mian M. Alauddin; Peter S. Conti; John D. Fissekis 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 77 KB 👁 1 views

## Abstract Several 2′‐deoxy‐2′‐[^18^F]fluoro‐1‐__β__‐D‐arabinofuranosyluracil derivatives have been synthesized. Coupling of 1‐bromo‐2‐deoxy‐2‐[^18^F]fluoro‐3,5‐di‐O‐benzoyl‐__α__‐D‐arabinofuranose **2** with protected uracil derivatives **3a–e** followed by hydrolysis and high‐performance liquid

A novel method for stereospecific fluori
A novel method for stereospecific fluorination at the 2′-arabino-position of pyrimidine nucleoside: synthesis of [18F]-FMAU
✍ Nashaat Turkman; Juri G. Gelovani; Mian M. Alauddin 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 169 KB

## Abstract Direct fluorination of a pyrimidine nucleoside at the 2′‐arabino‐position has been deemed to be extremely difficult, if not impossible. The conventional synthesis of 2′‐deoxy‐2′‐fluoro‐5‐methy‐1‐β‐D‐arabinofuranosyluracil (FMAU) and its 5‐substituted analogs involves stereospecific fluo