An enantio- and stereocontrolled synthesis of (–)-mycestericin E via cinchona alkaloid-catalyzed asymmetric Baylis–Hillman reaction
✍ Scribed by Iwabuchi, Yoshiharu; Furukawa, Mariko; Esumi, Tomoyuki; Hatakeyama, Susumi
- Book ID
- 121288872
- Publisher
- Royal Society of Chemistry
- Year
- 2001
- Tongue
- English
- Weight
- 81 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1359-7345
- DOI
- 10.1039/B106471C
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## Abstract Novel β‐amino esters bearing a bioactive benzothiazole moiety were obtained with high enantioselectivities (up to 95 % __ee__) through a Mannich‐type reaction of different imines with malonate in the presence of a new chiral cinchona alkaloid thiourea catalyst. Imines derived from both