✍ Scribed by Aamer Saeed; Nasim H. Rama; M. Arfan
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3,5‐Dimethoxyhomophthalic acid was prepared efficiently in three steps, from 3,5‐dimethoxybenzyl bromide via rhodium‐catalyzed direct carbonylation to 3,5‐dimethoxyphenylacetic acid followed by successive o‐formylation and oxidation. Isocoumarins related to agrimonolide and achlisocoumarin 1 were prepared in single step by condensation of the homophthalic acid with appropriate acid chlorides.
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A versatile intermediate ( 18) for optically active 5,6-ciscarbapenem antibiotics was synthesized with a highly regioselective intramolecular aldol condensation as a key step.
The Ziegler intermediate 2, previously used in three total syntheses of forskolin (1) has been synthesized efficiently from enone 3. The key transformation of this sequence is the early and stereoselective introduction of the C-6, C-7 oxygen functional groups present in the natural product. The hig
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