An efficient protocol for Sharpless-style racemic dihydroxylation
✍ Scribed by Eames, Jason; Mitchell, Helen J.; Nelson, Adam; O’Brien, Peter; Warren, Stuart; Wyatt, Paul
- Book ID
- 120871495
- Publisher
- Royal Society of Chemistry
- Year
- 1999
- Weight
- 266 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1472-7781
- DOI
- 10.1039/A900277D
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Dihydroxylation of ene ester systems was achieved in good yield and diastereoselectivity under classical catalytic OsO( and NMO conditions using the intrinsic diastereoselectivity in a-methyl ~-OTBS systems. This inlxinsic diastereoselection can be reversed using 'super' AD-mix to give the opposite
An Efficient Synthesis of (-)-Pestalotin and Its Enantiomer Using Sharpless Asymmetric Dihydroxylation. -The title compound (IV), a gibberellin synergist isolated from a phytopathogenic fungus Pestaltia cryptomeriaecola, is prepared using Sharpless asymmetric dihydroxylation as the key step. A simi