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An efficient Pd-catalyzed hydration of nitrile with acetaldoxime

✍ Scribed by Eun Sun Kim; Hoo Sook Kim; Jae Nyoung Kim

Book ID: 104096517
Publisher: Elsevier Science
Year: 2009
Tongue: French
Weight: 516 KB
Volume: 50
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2009.04.007

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✦ Synopsis

An efficient palladium-catalyzed protocol for the hydration of nitrile to amide with acetaldoxime has been developed. A plausible mechanism was suggested involving the first Pd(II)-catalyzed nitrile-oxime coupling and the following disruption of the intermediate into amide and acetonitrile in a concerted manner.

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