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An efficient approach toward the synthesis of phosphorothioate diesters via the schönberg reaction

✍ Scribed by P.C.J. Kamer; H.C.P.F. Roelen; H. van den Elst; G.A. van der Marel; J.H. van Boom

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
251 KB
Volume
30
Category
Article
ISSN
0040-4039

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✦ Synopsis

Easily accessible phenacetyl or benzoyl disulfide proved to be very convenient reagents for a rapid Psulfurttation of phosphfte-triesters and H-phosphonate diesters, respectively. Phosphorothioate (PS) analogues of nucleotides are useful probes to study phosphoryl and nucleotidyl transferring enzymes'~'. Further, PS analogues of nucleic acids are of great interest because of their potential use as anti-sense inhibitors!

The introduction of an internucleotide PS diester can be realized in two ways: i.e., via a phospho-or a phosphitetrfester approach. In the former case the PS function is either introduced in one step via phosphorothioylating reagents

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