Toward a novel approach to bis-β-lactam synthesis using Vilsmeier reagent as an efficient entity via Staudinger cycloaddition reaction

✍ Scribed by Jyotsna Meshram; Parvez Ali; Vandana Tiwari

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2010
• Tongue: English
• Weight: 119 KB
• Volume: 47
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.455

✦ Synopsis

Abstract

magnified image A facile synthesis of bis‐β‐lactams has been executed using chloromethylenedimethylammonium chloride (Vilsmeier reagent), prepared easily from N,N‐dimethylformamide and phosphorus oxychloride. It works out as a versatile acid activator reagent for the direct [2 + 2] ketene–imine cycloaddition of substituted acetic acid and bis‐imines in one‐pot synthesis under mild conditions. Thus, this method has been proved as a high yielding, efficient, and cheap protocol for bis‐β‐lactam synthesis. J. Heterocyclic Chem., (2010).