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An approach to the synthesis of α-l-fucopyranosyl phosphoric mono- and diesters via phosphite intermediates

✍ Scribed by P. Westerduin; G.H. Veeneman; J.E. Marugg; G.A. van der Marel; J.H. van Boom

Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
257 KB
Volume
27
Category
Article
ISSN
0040-4039

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✦ Synopsis

The reagent chloro-B-cyanoethyl-N,N-diisopropylamino-phosphoramidite reacts smoothly with the anomeric hydroxyl group of a properly protected (benzyl) a-L-fucopyranose to afford a relatively stable phosphite intermediate in high yield. The latter can easily be converted into valuable a-L-fucopyranosyl phosphoric mono-and diesters.

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