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A convenient and general approach to the synthesis of properly protected d-nucleoside-3′-hydrogenphosphonates via phosphite intermediates

✍ Scribed by J.E Marugg; M Tromp; E Kuyl-Yeheskiely; G.A van der Marel; J.H van Boom

Publisher: Elsevier Science
Year: 1986
Tongue: French
Weight: 246 KB
Volume: 27
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)84611-0

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✦ Synopsis

Evidence will be presented to show that the monofunctional phosphitylating reagents bis(N,N-di-ethylamino)chlorophosphine and salicylchlorophosphine are very effective for the preparation of 5'-O,N-protected d-nucleoside-3'-hydrogenphosphonates.

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