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A general approach to the synthesis of 2,3-di-O-protected derivatives of d-glyceraldehyde

✍ Scribed by Janusz Jurczak; Tomasz Bauer; Marek Chmielewski


Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
397 KB
Volume
164
Category
Article
ISSN
0008-6215

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✍ HΓ€fele, Brigitte ;JΓ€ger, Volker πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 English βš– 349 KB

Hydroxy-2-penten&lide (5) was synthesized in three stcps starting from mnannitol bidacetonide) (l), via Dglyceraldchydc acetonide (2) by Z-selective Wittig reaction, acid-catalyzed lactonization and crystallization with a total yield of 40%. (S)-S-Hydroxy-2-penten-4-0lide (S), the aglycone of ranun