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ChemInform Abstract: Stereocontrolled Synthesis of All Four Stereoisomers of Fully Protected 2-Amino-3-hydroxypentanoic Acid from Imines Derived from D-Glyceraldehyde.

โœ Scribed by Ramon Badorrey; Carlos Cativiela; Maria D. Diaz-de-Villegas; Jose A. Galvez


Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
31
Category
Article
ISSN
0931-7597

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ChemInform Abstract: New Amino Acids Der
โœ J. VAN BETSBRUGGE; W. VAN DEN NEST; P. VERHEYDEN; D. TOURWE ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 38 KB ๐Ÿ‘ 2 views

Pyroglutamic acid derivative (I) is proved to be an excellent chiral starting compound for the synthesis of title amino acids (IX), (X), and (V). The syntheses are based on a combination of methods previously used for the preparation of 4-and 5-substituted prolines. These methods are the ring openin