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An efficient and selective synthesis of nakienone A involving a novel protocol for α-alkenylation of ketones via palladium-catalyzed alkenyl-alkenyl coupling

✍ Scribed by Milan Pour; Ei-ichi Negishi

Book ID: 104256155
Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 233 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(96)02409-4

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✦ Synopsis

Nakienone A was synthesized for the first time from 3-methoxy-2-cyclopentenone, dienyl iodide 7, and LiCI-I2OMOM in 8 steps in 26% overall yield with full control of the alkene geometry using the Pal-catalyzed cross coupling reaction of a cyclopentenylzinc derivative 6a with 7 as a key step.

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