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ChemInform Abstract: A Selective Procedure for α-Alkenylation of Enones Involving Pd- Catalyzed Alkenyl-Alkenyl Coupling and Its Application to a Convergent and Efficient Synthesis of Nakienone B.

✍ Scribed by M. POUR; E. NEGISHI


Book ID
112038549
Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
27
Category
Article
ISSN
0931-7597

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An efficient and selective synthesis of
✍ Milan Pour; Ei-ichi Negishi 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 233 KB

Nakienone A was synthesized for the first time from 3-methoxy-2-cyclopentenone, dienyl iodide 7, and LiCI-I2OMOM in 8 steps in 26% overall yield with full control of the alkene geometry using the Pal-catalyzed cross coupling reaction of a cyclopentenylzinc derivative 6a with 7 as a key step.

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