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Highly Efficient and Selective Synthesis of Conjugated Triynes and Higher Oligoynes of Biological and Materials Chemical Interest via Palladium-Catalyzed Alkynyl—Alkenyl Coupling.

✍ Scribed by Estelle Metay; Qian Hu; Ei-ichi Negishi


Book ID
102000724
Publisher
John Wiley and Sons
Year
2007
Weight
24 KB
Volume
38
Category
Article
ISSN
0931-7597

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An efficient and selective synthesis of
✍ Milan Pour; Ei-ichi Negishi 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 233 KB

Nakienone A was synthesized for the first time from 3-methoxy-2-cyclopentenone, dienyl iodide 7, and LiCI-I2OMOM in 8 steps in 26% overall yield with full control of the alkene geometry using the Pal-catalyzed cross coupling reaction of a cyclopentenylzinc derivative 6a with 7 as a key step.