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Highly Efficient and Selective Synthesis of Conjugated Triynes and Higher Oligoynes of Biological and Materials Chemical Interest via Palladium-Catalyzed Alkynyl−Alkenyl Coupling †

✍ Scribed by Métay, Estelle; Hu, Qian; Negishi, Ei-ichi


Book ID
126777545
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
95 KB
Volume
8
Category
Article
ISSN
1523-7060

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An efficient and selective synthesis of
✍ Milan Pour; Ei-ichi Negishi 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 233 KB

Nakienone A was synthesized for the first time from 3-methoxy-2-cyclopentenone, dienyl iodide 7, and LiCI-I2OMOM in 8 steps in 26% overall yield with full control of the alkene geometry using the Pal-catalyzed cross coupling reaction of a cyclopentenylzinc derivative 6a with 7 as a key step.