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Amyloid Precursor Protein Processing and Alzheimer's Disease

✍ Scribed by O'Brien, Richard J.; Wong, Philip C.


Book ID
120278951
Publisher
Annual Reviews
Year
2011
Tongue
English
Weight
858 KB
Volume
34
Category
Article
ISSN
0147-006X

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## Abstract Proteolytic processing of the amyloid precursor protein by Ξ² ‐and γ‐secretases results in the production of Alzheimer's disease (AD) AΞ² amyloid peptides. Modulation of secretase activity is being investigated as a potential therapeutic approach. Recent studies with human brain have reve