## Abstract Proteolytic processing of the amyloid precursor protein by β ‐and γ‐secretases results in the production of Alzheimer's disease (AD) Aβ amyloid peptides. Modulation of secretase activity is being investigated as a potential therapeutic approach. Recent studies with human brain have reve
Key Factors in Alzheimer's Disease: β-amyloid Precursor Protein Processing, Metabolism and Intraneuronal Transport
✍ Scribed by Thomas A. Bayer; Oliver Wirths; Katalin Majtényi; Tobias Hartmann; Gerd Multhaup; Konrad Beyreuther; Christian Czech
- Book ID
- 111404105
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 236 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1015-6305
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Progressive cerebral deposition of -amyloid peptide either in blood vessels or around neurites is one of the most important features of Alzheimer's disease (AD). The -peptide, known as A or A4, is produced by proteolytic cleavage of the amyloid precursor protein (APP). Two APP processing pathways