## Abstract Proteolytic processing of the amyloid precursor protein by β ‐and γ‐secretases results in the production of Alzheimer's disease (AD) Aβ amyloid peptides. Modulation of secretase activity is being investigated as a potential therapeutic approach. Recent studies with human brain have reve
SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk
✍ Scribed by Christiane Reitz; Shinya Tokuhiro; Lorraine N. Clark; Christopher Conrad; Jean-Paul Vonsattel; Lili-Naz Hazrati; András Palotás; Raphael Lantigua; Martin Medrano; Ivonne Z. Jiménez -Velázquez; Badri Vardarajan; Irene Simkin; Jonathan L. Haines; Margaret A. Pericak -Vance; Lindsay A. Farrer; Joseph H. Lee; Ekaterina Rogaeva; Peter St. George- Hyslop; Richard Mayeux
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 923 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0364-5134
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## Abstract Linkage studies have suggested a susceptibility locus for late‐onset Alzheimer's disease (LOAD) on chromosome 21. A functional candidate gene in this region is the β‐amyloid precursor protein (APP) gene. Previously, coding mutations in APP have been associated with early onset Alzheimer