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Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer’s disease

✍ Scribed by Yan Ling; Kevin Morgan; Noor Kalsheker


Book ID
117756071
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
586 KB
Volume
35
Category
Article
ISSN
1357-2725

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## Abstract Proteolytic processing of the amyloid precursor protein by β ‐and γ‐secretases results in the production of Alzheimer's disease (AD) Aβ amyloid peptides. Modulation of secretase activity is being investigated as a potential therapeutic approach. Recent studies with human brain have reve