AMPLIFIED ALLELE OF THE HUMAN N-mycONCOGENE IN NEUROBLASTOMAS
โ Scribed by Yamada, Masao ;Kurosawa, Hidemitsu ;Nakagawa, Yuichi ;Nakagome, Yasuo ;Tsuda, Tohru ;Higashi, Ken
- Book ID
- 108578757
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1988
- Tongue
- English
- Weight
- 192 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0910-5050
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
MYCN amplification in neuroblastomas is strongly associated with advanced stages of disease and a poor prognosis. We have recently defined a 130 kb core region of the MYCN amplicon that is consistently amplified in neuroblastomas. However, it has been argued that other expressed sequences were coamp
Background and Procedure. The p53 gene homologue, p73, is located on the 1p36-3 locus, which is frequently deleted in human neuroblastoma (NB). A survey of 61 NB showed that among 33% of informative cases, p73 loss of heterozygosity (LOH) occurred in 7 of 20 (35%). Results. LOH pattern of vicinal ma