In vivoregulation of single copy and amplified N-myc in human neuroblastoma cells
β Scribed by Lutz, Werner; Schwab, Manfred
- Book ID
- 110060800
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 556 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Neuroblastoma, the most common extracranial solid tumor in children, arises from precursors of the sympathetic nervous system. Neuroblastoma cell lines are responsive to the differentiation agent retinoic acid, which induces its effects by altering transcription rates of specific target
In neuroblastoma, N-myc amplification has been found to be strikingly associated with rapid tumour progression and poor prognosis. Recent studies have demonstrated that cell proliferative activity also significantly predicts the clinical outcome in patients with neuroblastoma. In order to define the