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Amplification of the epidermal growth factor receptor gene in the BT20 breast carcinoma cell line

✍ Scribed by Jérome Lebeau; Gérard Goubin

Publisher
John Wiley and Sons
Year
1987
Tongue
French
Weight
572 KB
Volume
40
Category
Article
ISSN
0020-7136

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✦ Synopsis

Southern blot-hybridization analysis of 10 breast carcinoma cell lines demonstrated an amplification of the epidermal growth factor (EGF) receptor gene in the BTZO cell line. The gene was amplified 10to 14-fold when compared to the level seen in human placental DNA. Northern blot analysis indicated an increased level of transcription in this cell line which probably accounts for the high level of the EGF receptor reported in the BTZO cell line.

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