Topoisomerase II␣ (TOP2A) is a key enzyme in DNA replication and a molecular target for many important anticancer drugs. TOP2A is amplified or deleted together with amplification of the closely located ERBB2/HER-2/neu oncogene in breast cancer. We characterized the copy number aberrations of TOP2A a
✦ LIBER ✦
Amplification and Deletion of Topoisomerase IIα Associate with ErbB-2 Amplification and Affect Sensitivity to Topoisomerase II Inhibitor Doxorubicin in Breast Cancer
✍ Scribed by Tero A.H. Järvinen; Minna Tanner; Virpi Rantanen; Maarit Bärlund; Åke Borg; Seija Grénman; Jorma Isola
- Book ID
- 117022465
- Publisher
- American Society for Investigative Pathology
- Year
- 2000
- Tongue
- English
- Weight
- 1010 KB
- Volume
- 156
- Category
- Article
- ISSN
- 0002-9440
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