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Molecular subtypes of breast cancer and amplification of topoisomerase IIα: predictive role in dose intensive adjuvant chemotherapy

✍ Scribed by Hannemann, J; Kristel, P; van Tinteren, H; Bontenbal, M; van Hoesel, Q G C M; Smit, W M; Nooij, M A; Voest, E E; van der Wall, E; Hupperets, P


Book ID
109998992
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
166 KB
Volume
95
Category
Article
ISSN
0007-0920

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Topoisomerase II␣ (TOP2A) is a key enzyme in DNA replication and a molecular target for many important anticancer drugs. TOP2A is amplified or deleted together with amplification of the closely located ERBB2/HER-2/neu oncogene in breast cancer. We characterized the copy number aberrations of TOP2A a