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AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML

✍ Scribed by Licht, Jonathan D

Book ID
110064855
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
612 KB
Volume
20
Category
Article
ISSN
0950-9232

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## Abstract AML1‐ETO, a fusion protein generated by the chromosomal translocation t(8;21), is frequently associated with acute myeloid leukemia (AML). In addition to blocking differentiation, AML1‐ETO is also shown to induce growth arrest in AML cells, which is unfavorable for leukemogenesis harbor