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Molecular pathogenesis of AML (mouse models of acute myeloid leukemia with AML1-ETO fusion proteins)

✍ Scribed by Dong-Er Zhang

Book ID
105720633
Publisher
Carden Jennings Publishing
Year
2002
Tongue
English
Weight
207 KB
Volume
76
Category
Article
ISSN
0925-5710

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## Abstract The __AML1__ gene (also known as __RUNX1__) at 21q22 codes for core binding factor (CBF) Ξ±, which forms a heterodimer with CBF Ξ² that acts as a transcriptional activating factor. CBF is a critical regulator in the generation and differentiation of definitive hematopoietic stem cells and