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The t(8;21) fusion protein, AML1/ETO, transforms NIH3T3 cells and activates AP-1

✍ Scribed by Frank, Richard C; Sun, Xiao; Berguido, Francisco J; Jakubowiak, Andrzej; Nimer, Stephen D


Book ID
110061908
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
393 KB
Volume
18
Category
Article
ISSN
0950-9232

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Both Sp1 and Sp3 are responsible for p21
✍ Hengyi Xiao; Tadao Hasegawa; Ken-ichi Isobe πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 162 KB

Histone deacetylase inhibitor-induced expression of p21 WAF1 is p53 independent. In the present study, we provide evidence that trichostatin A (TSA), a specific inhibitor of histone deacetylase, can elevate H3 and H4 acetylation and p21 WAF1 expression in NIH3T3 cells at first. To identify the trans