AML1 amplification in a child with acute lymphoblastic leukemia
✍ Scribed by Yolanda Alvarez; M.D. Coll; P. Bastida; J.J. Ortega; M.R. Caballı́n
- Book ID
- 114135444
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 119 KB
- Volume
- 140
- Category
- Article
- ISSN
- 0165-4608
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## Abstract Fluorescence in situ hybridization (FISH) studies were performed in three cases of acute lymphoblastic leukemia (ALL) with marker chromosomes to analyze the contribution of chromosome 21 in these markers. FISH with a chromosome 21 painting probe confirmed that chromosome 21 was involved
Monosomy 21 and metacentric markers corresponding in size to chromosomes 8 to 12 were found as the only clonal chromosomal changes in a child with acute lymphoblastic leukemia (ALL). Chromosome painting with a whole chromosome 2 I -specific probe showed that the marker originated from chromosome 2 I