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A unique variant of ETV6/AML1 fusion in a child with acute lymphoblastic leukemia

✍ Scribed by Jalali, G R; Martineau, M; Ford, A M; Greaves, M; Stevens, R F; Harrison, C J


Book ID
110055420
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
116 KB
Volume
17
Category
Article
ISSN
0887-6924

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The ETV6 (TEL) locus at chromosome band 12p13 is a major site of translocations in acute leukemia, particularly in childhood acute lymphoblastic leukemia (ALL). In cases with translocations involving ETV6, the normal ETV6 allele is often deleted. In addition, loss of heterozygosity of ETV6 is freque