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Clonotypic analysis of acute lymphoblastic leukemia with a double TEL-AML1 fusion at onset and relapse

✍ Scribed by Inukai, T; Yokota, S; Okamoto, T; Nemoto, A; Akahane, K; Takahashi, K; Sato, H; Goi, K; Nakazawa, S; Sugita, K


Book ID
110056598
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
121 KB
Volume
20
Category
Article
ISSN
0887-6924

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TEL/AML1 gene fusion is the most frequent genetic lesion in pediatric acute lymphoblastic leukemia (ALL). It occurs as a consequence of the cryptic chromosomal translocation t(12;21)(p13;q22). In a cohort of 50 RT-PCR-positive TEL/AML1 patients, karyotype examination by GTG banding and fluorescence