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Partial chromosome 21 amplification in a child with acute lymphoblastic leukemia

✍ Scribed by Maryvonne Le Coniat; Serge P. Romana; Dr. Roland Berger

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
411 KB
Volume
14
Category
Article
ISSN
1045-2257

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✦ Synopsis

Monosomy 21 and metacentric markers corresponding in size to chromosomes 8 to 12 were found as the only clonal chromosomal changes in a child with acute lymphoblastic leukemia (ALL). Chromosome painting with a whole chromosome 2 I -specific probe showed that the marker originated from chromosome 2 I. Fluorescence in situ hybridization with yeast artificial chromosome (YAC) probes to chromosome 2 I showed genomic amplification with two, four, or more copies of the probed D N A sequences present on the marker. The most amplified regions of chromosome 21 were centromeric and telomeric to the Down's syndrome region. This observation supports the notion that amplification of only parts of chromosome 21 may be important in the leukemogenic process in spite of the high incidence of complete trisomy 21 in ALL. Genes Chromosom Cancer /4:204-209 (1995).

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