Amino acid structure and “difficult sequences” in solid phase peptide synthesis
✍ Scribed by BEDFORD, JOY ;HYDE, CAROLYN ;JOHNSON, T. ;JUN, WEN ;OWEN, D. ;QUIBELL, M. ;SHEPPARD, R.C.
- Book ID
- 115099323
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 661 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0367-8377
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📜 SIMILAR VOLUMES
S)-ctMethyimethionine, (S)-ctMethylleucine, 2-aminoisobutyric acid and (S)-otMethylphenylalanine have been incorporated by solid phase peptide strategy in a peptide sequence. The coupling reactions of these Boc-ctMe amino acids and of the following residue in the sequence were readily achieved afte
## Abstract This article illustrates the successful and efficient solid phase assembly of hydrophobic difficult sequence peptides following both __t__‐Boc and Fmoc chemistry. The peptides were synthesized on an optimized 1,4‐butanediol dimethacrylate‐crosslinked polystyrene support (BDDMA‐PS). Four